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apalutamide will minimize the extent or result of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a robust CYP2C19 inducer, with medicine that are CYP2C19 substrates may lead to reduce exposure to these drugs.enasidenib will improve the degree or effect of diazepam by impactin